Erythroblastosis Fetalis in the First-born Prevention of Its Most Severe Forms
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By PHILIP LEVINE, M.D., AND R. K. WALLER, M.D. A a result of our knowledge of the pathogenesis of erythroblastosis fetalis, a new diagnostic procedure, testing for the Rh factor, has been made available.” 2 Another outcome of the early work was the recommendation3 that human anti-Rh agglutinins derived from mothers of erythroblastotic infants are far preferable to experimental anti-Rh blood immune serum, which, by and large, is now no longer used.* Tests with potent diagnostic anti-Rh serums were recommended for all women with a history of fetal or neonatal morbidity, in order to prevent intragroup transfusion accidents, and for the selection of Rh negative blood for the affected infants of Rh negative mothers. The findings presented below indicate that future emphasis should be placed on the prevention of iso-immunization by transfusions in the group of Rh negative female patients at any time prior to possible pregnancies. Iso-immunization by the Rh factor occurs in two groups of cases, namely, (i)
منابع مشابه
IV. Antenatal prophylaxis in the prevention of Rh hemolytic disease of the fetus and newborn (HDN)
Gac Méd Méx Vol. 140, Suplemento No. 3, 2004 Rh haemolytic disease of the fetus and newborn (HDN) is a condition in which the lifespan of the infant’s red cells is shortened by the binding of specific IgG Rh antibodies produced by the mother, which transfer across the placenta. The disease begins in intra-uterine life and shows a wide spectrum of severity. Not all D-positive infants born to mot...
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